The Choso Tweaking meme originated from the anime Jujutsu Kaisen's Shibuya Arc, specifically S2 E13. The background behind the meme is that Choso, after killing Yuji Itadori, starts getting false memories, causing him to believe Yuji Itadori is his brother (Which technically isn't wrong, as is revealed later.) This clip is used in various short-form memes-usually with The Amazing Digital Circus theme song playing in the background-to show distress or 'tweaking'.
The original clip is this: https://www.youtube.com/watch?v=jgiWktcH_E8
Examples of this being used include this TikTok::http://www.tiktok.com/@meztroz/video/7293097511336840494?is_from_webapp=1&sender_device=pc